Approach the menopause with serenity

During the menopause, moderate to severe hot flushes pose a great social problem, notably in women who do not take hormone replacement therapy.

It is considered in the West that women's diet provides 5mg of phyto-oestrogens per day. Epidemiological studies have shown that in Asia, a diet rich in phyto-oestrogens (around 45mg per day) could explain the low prevalence of menopausal problems (1-2).

Albertazzi showed that in menopausal women suffering from very severe problems, a supplement rich in soya proteins (60mg per day) was able to reduce the number of hot flushes experienced (3).

Phyto Soya Study
Methodology comparable to that of the Albertazzi study
Participation of 75 menopausal women
Number of hot flushes >8
Follow-up of 4 months and dosage of 70mg/day
The dose of isoflavones used in the study, greater than that of the average consumption of Asian women, was justified because of the short duration of the study and the severity of the cases included in the study (greater than 8 hot flushes per day).

Evaluation of the efficiency of Phyto Soya versus the Placebo
It was observed after a 4-month treatment using PHYTO SOYA that the average reduction in number of hot flushes was -6.4 whereas it was only -2.2 in the placebo group. This difference between the two groups is statistically significant (p=0.0095).

The figure below shows the change in the number of hot flushes experienced over the 4-month study period (% reduction in hot flushes)

65.8 % of women experienced a reduction of at least 50% in the number of hot flushes experienced in the PHYTO SOYA group compared to only 32.4% in the placebo group (p=0.005)

The efficacy of the treatment was considered good to excellent by 72.9% of patients in the PHYTO SOYA group compared to only 39.4% in the placebo group (p=0.007).

More than 93% of women in the PHYTO SOYA group judged the tolerance to be good to excellent

(1) ADELCREUTZ H., FOTSIS T., WAHALA K. et al. - Determination of urinary lignans and phytoestrogen metabolites, potential anti-estrogens and anti-carcinogens, in urine of women on various habitual diets - J. Steroid Biochem. 1986; 25: 791-797
(2) ARNOLD S.F., KLOTZ D. M., Collins B.M. et al - Synergic activation of receptor with combinations of the environmental chemical. Science 1996; 272: 1489-1492
(3) ALBERTAZZI P., PANZINI F., BONACCORSI G., ZANOTTI L., ALOISSIO D. - The effect of dietary soy supplementation on hot flushes ' Obstet. Gynecol. 1998; 1: 6-10
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